Standard Name	MCD4 1
Systematic Name	YKL165C
Alias	ZRG16 2 , SSU21 3 , FSR2 4
Feature Type	ORF, Verified
Description	Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes (5)
Name Description	Morphogenesis Checkpoint Dependent 1

Chromosomal Location	ChrXI:140691 to 137932 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MCD4
Molecular Function
Manually curated	mannose-ethanolamine phosphotransferase activity (IMP)
Biological Process
Manually curated	ATP transport (IDA) GPI anchor biosynthetic process (IDA, IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) fungal-type cell wall (IDA) fungal-type vacuole (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
conditional	bud morphology: abnormal budding: decreased budding index: decreased budding index: increased endomembrane system morphology: abnormal heat sensitivity: increased resistance to fluphenazine: decreased resistance to copper(2+) sulfate: increased utilization of carbon source: absent vacuolar morphology: abnormal viability: decreased
null	cold sensitivity: increased inviable killer toxin resistance: decreased resistance to nystatin: decreased resistance to sodium dodecyl sulfate: decreased resistance to hygromycin B: decreased vegetative growth: decreased rate
reduction of function	cell size: increased resistance to calcium chloride: decreased resistance to magnesium chloride: decreased resistance to caffeine: decreased resistance to Calcofluor White: decreased vegetative growth: decreased
Large-scale survey
null	cell size: increased heat sensitivity: increased inviable
reduction of function	competitive fitness: increased telomere length: increased
repressible	cytokinesis: abnormal mitochondrial morphology: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	16 total interaction(s) for 15 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 PCA: 6
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 1 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:140691 to 137932 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2760 140691..137932 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001648