MCA1/YOR197W Summary

MCA1 BASIC INFORMATION

Standard Name	MCA1 1
Systematic Name	YOR197W
Alias	YCA1 2
Feature Type	ORF, Verified
Description	Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon hydrogen peroxide treatment; proposed to be involved in cell cycle progression (2, 3)
Name Description	MetaCAspase 1

GO Annotations	All MCA1 GO evidence and references
	View Computational GO annotations for MCA1
Molecular Function
Manually curated	cysteine-type peptidase activity (IDA)
Biological Process
Manually curated	apoptosis (IDA, IMP) cellular response to hydrogen peroxide (IMP)
Cellular Component
Manually curated	nucleus (IDA)

Mutant Phenotype	All MCA1 Phenotype details and references
Classical genetics
null	apoptosis: decreased cell cycle progression: abnormal cell cycle progression through the G1/S phase transition: delayed cell cycle progression through the G2/M phase transition: increased rate 20S proteasome activity: increased Rpt1p accumulation: decreased survival rate in stationary phase: decreased toxin resistance: increased viability: increased
overexpression	apoptosis: increased
Large-scale survey
null	apoptosis: decreased viable

Interactions	MCA1 All interactions details and references
	17 total interaction(s) for 13 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 1 Reconstituted Complex: 1 Two-hybrid: 6
Genetic Interactions	Dosage Lethality: 1 Phenotypic Suppression: 3 Synthetic Growth Defect: 1 Synthetic Rescue: 2

Sequence Information

ChrXV:717087 to 718385 | |

Last Update

Coordinates: 2006-05-11 | Sequence: 2006-05-11

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1299	717087..718385	2006-05-11	2006-05-11

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005723

MCA1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MCA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MCA1]

1)	Szallies A, et al. (2002) A metacaspase of Trypanosoma brucei causes loss of respiration competence and clonal death in the yeast Saccharomyces cerevisiae. FEBS Lett 517(1-3):144-50
2)	Madeo F, et al. (2002) A caspase-related protease regulates apoptosis in yeast. Mol Cell 9(4):911-7
3)	Lee RE, et al. (2008) A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics. PLoS ONE 3(8):e2956

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