MBF1/YOR298C-A Summary

MBF1 BASIC INFORMATION

Standard Name	MBF1
Systematic Name	YOR298C-A
Alias	SUF13
Feature Type	ORF, Verified
Description	Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations (1, 2)
Name Description	Multiprotein Bridging Factor 3

GO Annotations	All MBF1 GO evidence and references
	View Computational GO annotations for MBF1
Molecular Function
Manually curated	transcription coactivator activity (IDA)
Biological Process
Manually curated	positive regulation of transcription from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	nucleus (IC)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All MBF1 Phenotype details and references
Large-scale survey
null	glycogen accumulation: increased resistance to cycloheximide: decreased resistance to ethanol: decreased resistance to St. John's Wort extract: decreased toxin resistance: increased viable

Interactions	MBF1 All interactions details and references
	14 total interaction(s) for 11 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 2 Protein-RNA: 1 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 2

Sequence Information

ChrXV:877684 to 877229 | |

Note: this feature is encoded on the Crick strand.

Genetic position: 165 cM

Last Update

Coordinates: 2006-01-05 | Sequence: 2004-02-12

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..456	877684..877229	2006-01-05	2004-02-12

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000007253

MBF1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MBF1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MBF1]

1)	Culbertson MR, et al. (1982) Frameshift suppression in Saccharomyces cerevisiae. V. Isolation and genetic properties of nongroup-specific suppressors. Genetics 102(3):361-78
2)	Takemaru K, et al. (1998) Yeast coactivator MBF1 mediates GCN4-dependent transcriptional activation. Mol Cell Biol 18(9):4971-6
3)	Takemaru K, et al. (1997) Multiprotein bridging factor 1 (MBF1) is an evolutionarily conserved transcriptional coactivator that connects a regulatory factor and TATA element-binding protein. Proc Natl Acad Sci U S A 94(14):7251-6

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