MAK21/YDR060W Summary

MAK21 BASIC INFORMATION

Standard Name	MAK21
Systematic Name	YDR060W
Alias	NOC1
Feature Type	ORF, Verified
Description	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein (1, 2)
Name Description	MAintenance of Killer

GO Annotations	All MAK21 GO evidence and references
	View Computational GO annotations for MAK21
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ribosomal large subunit assembly (IMP)
Cellular Component
Manually curated	Noc1p-Noc2p complex (IPI)

Mutant Phenotype	All MAK21 Phenotype details and references
Large-scale survey
null	filamentous growth: increased invasive growth: absent inviable

Interactions	MAK21 All interactions details and references
	180 total interaction(s) for 99 unique genes/features.
Physical Interactions	Affinity Capture-MS: 154 Affinity Capture-RNA: 1 Affinity Capture-Western: 8 Co-fractionation: 2 PCA: 2
Genetic Interactions	Phenotypic Enhancement: 4 Phenotypic Suppression: 7 Synthetic Growth Defect: 1 Synthetic Lethality: 1

Sequence Information

ChrIV:570647 to 573724 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3078	570647..573724	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002467

MAK21 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MAK21

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MAK21]

1)	Edskes HK, et al. (1998) Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis. J Biol Chem 273(44):28912-20
2)	Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27

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