MAK11/YKL021C Summary Help

Standard Name MAK11 1
Systematic Name YKL021C
Feature Type ORF, Verified
Description Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats (2, 3)
Name Description MAintenance of Killer 4
Chromosomal Location
ChrXI:398750 to 397344 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -16 cM
Gene Ontology Annotations All MAK11 GO evidence and references
  View Computational GO annotations for MAK11
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
conditional
null
reduction of function
Resources
83 total interaction(s) for 72 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 53
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 8
  • Phenotypic Suppression: 4
  • Positive Genetic: 14

Resources
Expression Summary
histogram
Resources
Length (a.a.) 468
Molecular Weight (Da) 53,672
Isoelectric Point (pI) 8.58
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:398750 to 397344 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -16 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1407 398750..397344 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001504
References cited on this page View Complete Literature Guide for MAK11
1) Icho T, et al.  (1986) Molecular characterization of chromosomal genes affecting double-stranded RNA replication in Saccharomyces cerevisiae. Basic Life Sci 40:165-71
2) Icho T and Wickner RB  (1988) The MAK11 protein is essential for cell growth and replication of M double-stranded RNA and is apparently a membrane-associated protein. J Biol Chem 263(3):1467-75
3) Saveanu C, et al.  (2007) The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors. Mol Cell Biol 27(8):2897-909
4) Wickner RB  (1974) Chromosomal and nonchromosomal mutations affecting the "killer character" of Saccharomyces cerevisiae. Genetics 76(3):423-32