MAK11/YKL021C Summary Help

Standard Name MAK11 1
Systematic Name YKL021C
Feature Type ORF, Verified
Description Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats (2, 3)
Name Description MAintenance of Killer 4
Chromosomal Location
ChrXI:398750 to 397344 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -16 cM
Gene Ontology Annotations All MAK11 GO evidence and references
  View Computational GO annotations for MAK11
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 88 genes
Resources
Classical genetics
null
Large-scale survey
conditional
null
reduction of function
Resources
83 total interaction(s) for 72 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 53
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 8
  • Phenotypic Suppression: 4
  • Positive Genetic: 14

Resources
Expression Summary
histogram
Resources
Length (a.a.) 468
Molecular Weight (Da) 53,672
Isoelectric Point (pI) 8.58
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:398750 to 397344 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -16 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1407 398750..397344 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001504
References cited on this page View Complete Literature Guide for MAK11
1) Icho T, et al.  (1986) Molecular characterization of chromosomal genes affecting double-stranded RNA replication in Saccharomyces cerevisiae. Basic Life Sci 40:165-71
2) Icho T and Wickner RB  (1988) The MAK11 protein is essential for cell growth and replication of M double-stranded RNA and is apparently a membrane-associated protein. J Biol Chem 263(3):1467-75
3) Saveanu C, et al.  (2007) The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors. Mol Cell Biol 27(8):2897-909
4) Wickner RB  (1974) Chromosomal and nonchromosomal mutations affecting the "killer character" of Saccharomyces cerevisiae. Genetics 76(3):423-32