Standard Name	MAK10
Systematic Name	YEL053C
Alias	NAA35 1
Feature Type	ORF, Verified
Description	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible (2, 3)
Name Description	MAintenance of Killer 4

Chromosomal Location	ChrV:56102 to 53901 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -43 cM

	View Computational GO annotations for MAK10
Molecular Function
Manually curated	contributes_to peptide alpha-N-acetyltransferase activity (IMP)
Biological Process
Manually curated	N-terminal protein amino acid acetylation (IMP)
Cellular Component
Manually curated	NatC complex (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	mitophagy: decreased Mak3p accumulation: decreased Imh1p-GFP distribution: abnormal Trm1p-II-GFP distribution: abnormal Arl1p-GFP distribution: abnormal
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased mitophagy: decreased resistance to hydroxyurea: increased resistance to camptothecin: increased resistance to hydrogen chloride: increased resistance to hygromycin B: decreased resistance to amiodarone: decreased resistance to sirolimus: decreased resistance to sodium arsenite: decreased resistance to neothyonidioside: decreased resistance to fenpropimorph: decreased resistance to fluconazole: decreased resistance to methyl methanesulfonate: decreased resistance to dimethyl sulfoxide: decreased resistance to wortmannin: normal resistance to L-canavanine: increased telomere length: increased vegetative growth: decreased rate vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	40 total interaction(s) for 30 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Biochemical Activity: 1 Reconstituted Complex: 3 Two-hybrid: 5
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 2 Phenotypic Suppression: 1 Synthetic Growth Defect: 12 Synthetic Lethality: 7 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:56102 to 53901 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -43 cM
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2202 56102..53901 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000779