MAK10/YEL053C Summary

MAK10 BASIC INFORMATION

Standard Name	MAK10
Systematic Name	YEL053C
Alias	NAA35 1
Feature Type	ORF, Verified
Description	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible (2, 3)
Name Description	MAintenance of Killer

GO Annotations	All MAK10 GO evidence and references
	View Computational GO annotations for MAK10
Molecular Function
Manually curated	contributes_to peptide alpha-N-acetyltransferase activity (IMP)
Biological Process
Manually curated	N-terminal protein amino acid acetylation (IMP)
Cellular Component
Manually curated	NatC complex (IDA)
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All MAK10 Phenotype details and references
Classical genetics
null	Trm1p-II-GFP distribution: abnormal
Large-scale survey
null	resistance to rapamycin: decreased resistance to wortmannin: normal resistance to hygromycin B: decreased resistance to amiodarone: decreased telomere length: increased viable

Interactions	MAK10 All interactions details and references
	31 total interaction(s) for 22 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Biochemical Activity: 1 Two-hybrid: 5
Genetic Interactions	Phenotypic Suppression: 1 Synthetic Growth Defect: 11 Synthetic Lethality: 7

Sequence Information

ChrV:56102 to 53901 | |

Note: this feature is encoded on the Crick strand.

Genetic position: -43 cM

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2202	56102..53901	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000779

MAK10 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MAK10

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MAK10]

1)	Polevoda B, et al. (2009) A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. BMC Proc 3 Suppl 6:S2
2)	Wickner RB and Leibowitz MJ (1976) Chromosomal genes essential for replication of a double-stranded RNA plasmid of Saccharomyces cerevisiae: the killer character of yeast. J Mol Biol 105(3):427-43
3)	Polevoda B and Sherman F (2001) NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. J Biol Chem 276(23):20154-9

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