MAK10/YEL053C Summary Help

Standard Name MAK10 1
Systematic Name YEL053C
Alias NAA35 2
Feature Type ORF, Verified
Description Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; expression is glucose-repressible (3, 4)
Name Description MAintenance of Killer 5
Chromosomal Location
ChrV:56102 to 53901 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -43 cM
Gene Ontology Annotations All MAK10 GO evidence and references
  View Computational GO annotations for MAK10
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
41 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Biochemical Activity: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 2
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 7
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 733
Molecular Weight (Da) 84,302
Isoelectric Point (pI) 5.72
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:56102 to 53901 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -43 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2202 56102..53901 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000779
References cited on this page View Complete Literature Guide for MAK10
1) Wickner RB and Toh-e A  (1982) [HOK], a new yeast non-Mendelian trait, enables a replication-defective killer plasmid to be maintained. Genetics 100(2):159-74
2) Polevoda B, et al.  (2009) A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. BMC Proc 3 Suppl 6:S2
3) Wickner RB and Leibowitz MJ  (1976) Chromosomal genes essential for replication of a double-stranded RNA plasmid of Saccharomyces cerevisiae: the killer character of yeast. J Mol Biol 105(3):427-43
4) Polevoda B and Sherman F  (2001) NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. J Biol Chem 276(23):20154-9
5) Wickner RB  (1974) Chromosomal and nonchromosomal mutations affecting the "killer character" of Saccharomyces cerevisiae. Genetics 76(3):423-32