LSP1/YPL004C Summary

LSP1 BASIC INFORMATION

Standard Name	LSP1 1, 2
Systematic Name	YPL004C
Feature Type	ORF, Verified
Description	Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways (2, 3)
Name Description	Long chain bases Stimulate Phosphorylation 2

GO Annotations	All LSP1 GO evidence and references
	View Computational GO annotations for LSP1
Molecular Function
Manually curated	protein kinase inhibitor activity (IMP)
Biological Process
Manually curated	endocytosis (IGI, IMP) response to heat (IMP)
Cellular Component
Manually curated	eisosome (IDA)
High-throughput	cytoplasm (IDA) mitochondrial outer membrane (IDA) mitochondrion (IDA) plasma membrane enriched fraction (IDA)

Mutant Phenotype	All LSP1 Phenotype details and references
Large-scale survey
null	heat sensitivity: increased viable

Interactions	LSP1 All interactions details and references
	96 total interaction(s) for 85 unique genes/features.
Physical Interactions	Affinity Capture-MS: 54 Affinity Capture-RNA: 2 Biochemical Activity: 3 PCA: 22 Two-hybrid: 13
Genetic Interactions	Phenotypic Suppression: 1 Synthetic Haploinsufficiency: 1

Sequence Information

ChrXVI:551654 to 550629 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1026	551654..550629	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005925

LSP1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for LSP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for LSP1]

1)	Samanta MP and Liang S (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
2)	Zhang X, et al. (2004) Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p. J Biol Chem 279(21):22030-8
3)	Walther TC, et al. (2006) Eisosomes mark static sites of endocytosis. Nature 439(7079):998-1003

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