LSM12/YHR121W Summary Help

Standard Name LSM12 1
Systematic Name YHR121W
Feature Type ORF, Verified
Description Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress (1, 2, 3, 4)
Name Description Like SM
Chromosomal Location
ChrVIII:352756 to 353319 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LSM12 GO evidence and references
  View Computational GO annotations for LSM12
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 68 genes
Resources
Large-scale survey
null
Resources
121 total interaction(s) for 101 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 83
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • PCA: 2
  • Two-hybrid: 6

Genetic Interactions
  • Negative Genetic: 11
  • Positive Genetic: 10
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 187
Molecular Weight (Da) 21,313
Isoelectric Point (pI) 10.18
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:352756 to 353319 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..564 352756..353319 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001163
References cited on this page View Complete Literature Guide for LSM12
1) Albrecht M and Lengauer T  (2004) Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. FEBS Lett 569(1-3):18-26
2) Fleischer TC, et al.  (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307
3) Lee MW, et al.  (2007) Global protein expression profiling of budding yeast in response to DNA damage. Yeast 24(3):145-54
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76