Standard Name	LSG1 1
Systematic Name	YGL099W
Alias	KRE35
Feature Type	ORF, Verified
Description	Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm (1, 2)
Name Description	Large-Subunit Gtpase 1

Chromosomal Location	ChrVII:314631 to 316553 | ORF Map | GBrowse

	View Computational GO annotations for LSG1
Molecular Function
Manually curated	GTPase activity (ISS)
Biological Process
Manually curated	ascospore formation (IMP) conjugation with cellular fusion (IMP) ribosomal large subunit assembly (IMP) ribosomal subunit export from nucleus (IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IDA) cytosolic large ribosomal subunit (IDA)
High-throughput	mating projection tip (IDA)

Regulatory modules	predicted: stressResponse (559, 505, 451)

Classical genetics
null	cold sensitivity: increased mating efficiency: decreased Slt2p modification: increased sporulation efficiency: decreased viable
Large-scale survey
null	inviable
reduction of function	competitive fitness: increased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	145 total interaction(s) for 65 unique genes/features.
Physical Interactions	Affinity Capture-MS: 72 Affinity Capture-RNA: 1 Affinity Capture-Western: 49 Biochemical Activity: 2 Co-purification: 9 PCA: 4 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 4 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:314631 to 316553 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1923 314631..316553 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003067