LRS4/YDR439W Summary Help

LRS4 BASIC INFORMATION

Standard Name LRS4 1
Systematic Name YDR439W
Feature Type ORF, Verified
Description Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation (1, 2, 3)
Name Description Loss of RDNA Silencing 1
GO Annotations All LRS4 GO evidence and references
    View Computational GO annotations for LRS4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All LRS4 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions LRS4 All interactions details and references
246 total interaction(s) for 192 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-Western: 4
  • Biochemical Activity: 6
  • Co-localization: 1
  • Two-hybrid: 7
Genetic Interactions
  • Phenotypic Enhancement: 35
  • Phenotypic Suppression: 69
  • Synthetic Growth Defect: 81
  • Synthetic Lethality: 19
  • Synthetic Rescue: 1
Sequence Information
ChrIV:1339669 to 1340712 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1044 1339669..1340712 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002847

LRS4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for LRS4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for LRS4]

1) Smith JS, et al.  (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97
2) Rabitsch KP, et al.  (2003) Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell 4(4):535-48
3) Johzuka K and Horiuchi T  (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35