LRO1/YNR008W Summary Help

Standard Name LRO1 1
Systematic Name YNR008W
Feature Type ORF, Verified
Description Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase (1, 2)
Name Description Lecithin cholesterol acyl transferase Related Open reading frame 1
Chromosomal Location
ChrXIV:640396 to 642381 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LRO1 GO evidence and references
  View Computational GO annotations for LRO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
overexpression
Resources
69 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Co-purification: 1

Genetic Interactions
  • Negative Genetic: 24
  • Phenotypic Enhancement: 22
  • Phenotypic Suppression: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 661
Molecular Weight (Da) 75,393
Isoelectric Point (pI) 6.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:640396 to 642381 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1986 640396..642381 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005291
References cited on this page View Complete Literature Guide for LRO1
1) Oelkers P, et al.  (2000) A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast. J Biol Chem 275(21):15609-12
2) Voynova NS, et al.  (2012) A novel pathway of ceramide metabolism in Saccharomyces cerevisiae. Biochem J 447(1):103-14