LOT6/YLR011W Summary Help

Standard Name LOT6 1
Systematic Name YLR011W
Feature Type ORF, Verified
Description FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions (1, 2, 3)
Name Description LOw Temperature-responsive 1
Chromosomal Location
ChrXII:169103 to 169678 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LOT6 GO evidence and references
  View Computational GO annotations for LOT6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 51 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
18 total interaction(s) for 17 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 5
  • Positive Genetic: 5
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 191
Molecular Weight (Da) 21,280
Isoelectric Point (pI) 6.03
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:169103 to 169678 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..576 169103..169678 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004001
References cited on this page View Complete Literature Guide for LOT6
1) Zhang L, et al.  (2001) Multiple mechanisms regulate expression of low temperature responsive (LOT) genes in Saccharomyces cerevisiae. Biochem Biophys Res Commun 283(2):531-5
2) Sollner S, et al.  (2007) Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification. FEBS J 274(5):1328-39
3) Sollner S, et al.  (2009) The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis. FEMS Yeast Res 9(6):885-91