Standard Name	LOS1
Systematic Name	YKL205W
Feature Type	ORF, Verified
Description	Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm (1, 2, 3, 4)
Name Description	Loss Of Suppression 5

Chromosomal Location	ChrXI:50051 to 53353 | ORF Map | GBrowse
	Genetic position: -149.7 cM

	View Computational GO annotations for LOS1
Molecular Function
Manually curated	Ran GTPase binding (IDA) tRNA binding (TAS)
Biological Process
Manually curated	tRNA export from nucleus (IMP) tRNA re-export from nucleus (IGI) tRNA splicing, via endonucleolytic cleavage and ligation (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nuclear matrix (IDA)
High-throughput	integral to membrane (ISM) mitochondrion (IDA)

Classical genetics
null	tRNA-Ile-UAU accumulation: increased tellurium atom accumulation: increased Rpl7b-GFP distribution: abnormal resistance to 5-fluorouracil: decreased resistance to tellurite: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to bleomycin: increased resistance to camptothecin: increased resistance to sirolimus: increased resistance to 5-fluorouracil: decreased resistance to propolis extract: decreased resistance to cycloheximide: decreased resistance to tunicamycin: increased resistance to sirolimus: decreased vacuolar morphology: abnormal viable
overexpression	inviable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	111 total interaction(s) for 81 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 7 Reconstituted Complex: 4 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 6 Negative Genetic: 41 Phenotypic Suppression: 3 Positive Genetic: 5 Synthetic Growth Defect: 23 Synthetic Lethality: 6 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:50051 to 53353 | ORF Map | GBrowse
	Genetic position: -149.7 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3303 50051..53353 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001688