Standard Name	LOA1 1
Systematic Name	YPR139C
Alias	VPS66 2
Feature Type	ORF, Verified
Description	Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA (1, 3)
Name Description	Lysophosphatidic acid: Oleoyl-CoA Acyltransferase 1

Chromosomal Location	ChrXVI:814058 to 813156 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for LOA1
Molecular Function
Manually curated	lysophosphatidic acid acyltransferase activity (IDA)
Biological Process
Manually curated	cellular triglyceride homeostasis (IMP) lipid particle organization (IMP)
High-throughput	protein targeting to vacuole (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) lipid particle (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	cell size: increased lipid particle morphology: abnormal viable
overexpression	lipid particle morphology: abnormal
Large-scale survey
null	auxotrophy cell cycle progression in G1 phase: increased duration cell size: increased proton accumulation: increased glycogen accumulation: increased polyphosphate accumulation: abnormal inositol excretion: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate haploinsufficient heat sensitivity: increased ionic stress resistance: decreased lipid particle morphology: abnormal metal resistance: decreased resistance to oleate: decreased resistance to ethanol: decreased resistance to acetic acid: decreased resistance to quinine: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to mefloquine: decreased resistance to paromomycin: decreased resistance to neomycin: decreased resistance to cycloheximide: decreased resistance to sorbate: decreased vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	17 total interaction(s) for 17 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Biochemical Activity: 3 PCA: 1 Protein-peptide: 2 Reconstituted Complex: 1
Genetic Interactions	Negative Genetic: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:814058 to 813156 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..903 814058..813156 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006343