Standard Name	LHP1 1
Systematic Name	YDL051W
Alias	LAH1 , YLA1
Feature Type	ORF, Verified
Description	RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen (2, 3, 4)
Name Description	La-Homologous Protein 1
Gene Product Alias	La protein 2

Chromosomal Location	ChrIV:363952 to 364779 | ORF Map | GBrowse

	View Computational GO annotations for LHP1
Molecular Function
Manually curated	RNA binding (IDA) tRNA binding (IDA)
Biological Process
Manually curated	tRNA processing (IMP)
Cellular Component
Manually curated	nucleolus (IDA) nucleoplasm (IDA) nucleus (IDA)

Classical genetics
null	resistance to sirolimus: increased
unspecified	transposable element transposition: decreased
Large-scale survey
null	competitive fitness: increased resistance to streptomycin: decreased resistance to mycophenolic acid: decreased resistance to methyl methanesulfonate: increased resistance to hydroxyurea: increased resistance to amitrole: decreased resistance to fenpropimorph: increased resistance to caffeine: increased resistance to cycloheximide: increased resistance to bleomycin: increased resistance to cycloheximide: decreased resistance to fluconazole: increased vacuolar morphology: abnormal viable
overexpression	resistance to sirolimus: increased vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	132 total interaction(s) for 94 unique genes/features.
Physical Interactions	Affinity Capture-MS: 38 Affinity Capture-RNA: 3 Affinity Capture-Western: 1 Biochemical Activity: 7 Protein-peptide: 5 Reconstituted Complex: 2
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 4 Negative Genetic: 36 Phenotypic Suppression: 4 Positive Genetic: 15 Synthetic Growth Defect: 5 Synthetic Lethality: 8 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:363952 to 364779 | ORF Map | GBrowse
Last Update	Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..828 363952..364779 2004-02-11 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002209