LHP1/YDL051W Summary Help

Standard Name LHP1 1
Systematic Name YDL051W
Alias LAH1 , YLA1
Feature Type ORF, Verified
Description RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen (2, 3, 4)
Name Description La-Homologous Protein 1
Gene Product Alias La protein 2
Chromosomal Location
ChrIV:363952 to 364779 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LHP1 GO evidence and references
  View Computational GO annotations for LHP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
Resources
137 total interaction(s) for 96 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 41
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 1
  • Biochemical Activity: 7
  • Co-fractionation: 1
  • Protein-peptide: 5
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 4
  • Negative Genetic: 36
  • Phenotypic Suppression: 4
  • Positive Genetic: 15
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 8
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 275
Molecular Weight (Da) 32,104
Isoelectric Point (pI) 9.02
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:363952 to 364779 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..828 363952..364779 2004-02-11 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002209
References cited on this page View Complete Literature Guide for LHP1
1) Yoo CJ and Wolin SL  (1994) La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth. Mol Cell Biol 14(8):5412-24
2) Yoo CJ and Wolin SL  (1997) The yeast La protein is required for the 3' endonucleolytic cleavage that matures tRNA precursors. Cell 89(3):393-402
3) Lin-Marq N and Clarkson SG  (1995) A yeast RNA binding protein that resembles the human autoantigen La. J Mol Biol 245(2):81-5
4) Pannone BK, et al.  (1998) A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts. EMBO J 17(24):7442-53