Standard Name	LGE1
Systematic Name	YPL055C
Feature Type	ORF, Verified
Description	Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division (1, 2)
Name Description	LarGE cells 1

Chromosomal Location	ChrXVI:454990 to 453992 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for LGE1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	histone methylation (IMP) histone ubiquitination (IMP) premeiotic DNA replication (IMP) protein monoubiquitination (IMP)
High-throughput	regulation of cell size (IGI, IMP)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	UV resistance: decreased chromosome/plasmid maintenance: abnormal colony sectoring: increased meiosis: abnormal resistance to hydroxyurea: decreased
Large-scale survey
null	UV resistance: decreased auxotrophy cell size: increased chitin deposition: normal colony sectoring: increased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased resistance to cycloheximide: decreased resistance to cadmium dichloride: decreased resistance to sirolimus: increased resistance to fenpropimorph: increased resistance to Calcofluor White: decreased resistance to hydroxyurea: decreased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to caffeine: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to sodium selenide: decreased resistance to wortmannin: normal resistance to BPS: decreased resistance to lovastatin: decreased resistance to sodium arsenite: decreased resistance to doxorubicin: decreased sporulation: decreased sporulation efficiency: decreased vegetative growth: decreased rate viable
overexpression	silencing: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	831 total interaction(s) for 455 unique genes/features.
Physical Interactions	Affinity Capture-MS: 56 Affinity Capture-RNA: 2 Co-localization: 1 PCA: 1 Two-hybrid: 13
Genetic Interactions	Negative Genetic: 398 Phenotypic Enhancement: 5 Phenotypic Suppression: 1 Positive Genetic: 74 Synthetic Growth Defect: 169 Synthetic Lethality: 103 Synthetic Rescue: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:454990 to 453992 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..999 454990..453992 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005976