Standard Name	LEA1 1
Systematic Name	YPL213W
Feature Type	ORF, Verified
Description	Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein (1)
Name Description	Looks Exceptionally like U2A 1

Chromosomal Location	ChrXVI:150614 to 151330 | ORF Map | GBrowse

	View Computational GO annotations for LEA1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mRNA splicing, via spliceosome (IMP)
Cellular Component
Manually curated	U2 snRNP (IDA, IPI) U2-type prespliceosome (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	heat sensitivity: increased vegetative growth: decreased rate
Large-scale survey
null	acid pH resistance: decreased chitin deposition: normal competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased inviable resistance to benomyl: decreased resistance to wortmannin: decreased resistance to acetic acid: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to cycloheximide: decreased resistance to caffeine: decreased resistance to oleate: decreased resistance to ethanol: decreased resistance to amitrole: decreased resistance to Calcofluor White: decreased resistance to tunicamycin: increased resistance to mycophenolic acid: increased resistance to methyl methanesulfonate: increased resistance to camptothecin: increased resistance to bleomycin: increased stress resistance: increased telomere length: increased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	518 total interaction(s) for 290 unique genes/features.
Physical Interactions	Affinity Capture-MS: 201 Affinity Capture-RNA: 4 Affinity Capture-Western: 3 Co-localization: 1 Co-purification: 1 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 227 Positive Genetic: 41 Synthetic Growth Defect: 21 Synthetic Lethality: 16
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:150614 to 151330 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..717 150614..151330 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006134