Standard Name	LDB18 1
Systematic Name	YLL049W
Feature Type	ORF, Verified
Description	Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 (1, 2, 3)
Name Description	Low Dye Binding 1

Chromosomal Location	ChrXII:40666 to 41205 | ORF Map | GBrowse

Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	establishment of mitotic spindle orientation (IMP)
Cellular Component
Manually curated	colocalizes_with astral microtubule (IDA) colocalizes_with cell cortex (IDA) dynactin complex (IDA) colocalizes_with spindle pole body (IDA)

Classical genetics
null	nuclear position: abnormal viable
Large-scale survey
null	bud morphology: abnormal competitive fitness: decreased haploinsufficient metal resistance: increased resistance to bleomycin: increased resistance to cycloheximide: decreased resistance to neomycin: decreased resistance to fluconazole: increased resistance to propolis extract: decreased resistance to camptothecin: decreased resistance to caffeine: decreased resistance to tunicamycin: decreased resistance to sodium arsenite: decreased stress resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	245 total interaction(s) for 141 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 4 Affinity Capture-Western: 10 Co-fractionation: 3 Two-hybrid: 15
Genetic Interactions	Negative Genetic: 162 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 25 Synthetic Growth Defect: 8 Synthetic Lethality: 16
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:40666 to 41205 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..540 40666..41205 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003972