KTR3/YBR205W Summary Help

Standard Name KTR3 1
Systematic Name YBR205W
Feature Type ORF, Verified
Description Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress (2, 3, 4)
Name Description Kre Two Related 5
Chromosomal Location
ChrII:633622 to 634836 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All KTR3 GO evidence and references
  View Computational GO annotations for KTR3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 6 genes
Resources
Large-scale survey
null
overexpression
Resources
60 total interaction(s) for 49 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Co-fractionation: 1
  • Co-localization: 1
  • Co-purification: 4
  • Two-hybrid: 10

Genetic Interactions
  • Negative Genetic: 23
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 404
Molecular Weight (Da) 47,482
Isoelectric Point (pI) 9.15
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:633622 to 634836 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1215 633622..634836 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000409
References cited on this page View Complete Literature Guide for KTR3
1) Bussereau F, et al.  (1993) A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1,2 gene, contains five putative new genes. Yeast 9(7):797-806
2) Lussier M, et al.  (1996) Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family. J Biol Chem 271(18):11001-8
3) Bue CA and Barlowe C  (2009) Molecular dissection of Erv26p identifies separable cargo binding and coat protein sorting activities. J Biol Chem 284(36):24049-60
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Lussier M, et al.  (1997) Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism. Yeast 13(3):267-74