KRE6/YPR159W Summary Help

Standard Name KRE6 1
Systematic Name YPR159W
Alias CWH48
Feature Type ORF, Verified
Description Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication (2, 3, 4)
Name Description Killer toxin REsistant 5
Chromosomal Location
ChrXVI:857583 to 859745 | ORF Map | GBrowse
Gbrowse
Genetic position: 95.9 cM
Gene Ontology Annotations All KRE6 GO evidence and references
  View Computational GO annotations for KRE6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant phenotypes All KRE6 Phenotype evidence and references
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
unspecified
Resources
interactions All KRE6 Interaction evidence and references
87 total interaction(s) for 70 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-Western: 6
  • Two-hybrid: 4
Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 5
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 16
  • Synthetic Lethality: 28
  • Synthetic Rescue: 4
Resources
Expression Summary
histogram
Resources
Protein Information All KRE6 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:857583 to 859745 | ORF Map | GBrowse
SGD ORF map
Genetic position: 95.9 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2163 857583..859745 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006363
References cited on this page View Complete Literature Guide for KRE6
1) Roemer T and Bussey H  (1991) Yeast beta-glucan synthesis: KRE6 encodes a predicted type II membrane protein required for glucan synthesis in vivo and for glucan synthase activity in vitro. Proc Natl Acad Sci U S A 88(24):11295-9
2) Roemer T, et al.  (1993) SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis. Mol Cell Biol 13(7):4039-48
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Kurita T, et al.  (2011) Kre6 Protein Essential for Yeast Cell Wall {beta}-1,6-Glucan Synthesis Accumulates at Sites of Polarized Growth. J Biol Chem 286(9):7429-38
5) Al-Aidroos K and Bussey H  (1978) Chromosomal mutants of Saccharomyces cerevisiae affecting the cell wall binding site for killer factor. Can J Microbiol 24(3):228-37