KIP3/YGL216W Summary Help

Standard Name KIP3 1
Systematic Name YGL216W
Feature Type ORF, Verified
Description Kinesin-related antiparallel sliding motor protein involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; also inhibits spindle elongation and promotes spindle disassembly in late anaphase (2, 3)
Name Description KInesin related Protein 1
Chromosomal Location
ChrVII:84885 to 87302 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All KIP3 GO evidence and references
  View Computational GO annotations for KIP3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
219 total interaction(s) for 113 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Biochemical Activity: 1
  • Co-fractionation: 2
  • Reconstituted Complex: 3
  • Two-hybrid: 12

Genetic Interactions
  • Negative Genetic: 113
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 2
  • Positive Genetic: 9
  • Synthetic Growth Defect: 22
  • Synthetic Lethality: 40
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 805
Molecular Weight (Da) 91,090
Isoelectric Point (pI) 7.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:84885 to 87302 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2418 84885..87302 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003184
References cited on this page View Complete Literature Guide for KIP3
1) DeZwaan TM, et al.  (1997) Kinesin-related KIP3 of Saccharomyces cerevisiae is required for a distinct step in nuclear migration. J Cell Biol 138(5):1023-40
2) Cottingham FR and Hoyt MA  (1997) Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins. J Cell Biol 138(5):1041-53
3) Su X, et al.  (2013) Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control. Nat Cell Biol 15(8):948-57