Standard Name	KIN4 (see Nomenclature conflict Note)
Systematic Name	YOR233W
Alias	KIN31 , KIN3 1
Feature Type	ORF, Verified
Description	Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description	KINase 1, 6

Chromosomal Location	ChrXV:775846 to 778248 | ORF Map | GBrowse

	View Computational GO annotations for KIN4
Molecular Function
Manually curated	protein serine/threonine kinase activity (ISS)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	mitotic spindle orientation checkpoint (IGI, IMP) protein phosphorylation (ISS)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	cell cortex (IDA) cellular bud neck (IDA) spindle pole body (IDA)

Classical genetics
overexpression	cell cycle progression in G2 phase: abnormal
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to cycloheximide: decreased sporulation: normal stress resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
overexpression	inviable vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	223 total interaction(s) for 160 unique genes/features.
Physical Interactions	Affinity Capture-MS: 23 Affinity Capture-RNA: 1 Affinity Capture-Western: 7 Biochemical Activity: 21 PCA: 1 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 37 Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 84 Phenotypic Enhancement: 2 Phenotypic Suppression: 4 Positive Genetic: 11 Synthetic Growth Defect: 2 Synthetic Lethality: 1 Synthetic Rescue: 24
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:775846 to 778248 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2403 775846..778248 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005759