Standard Name	KIC1 1 (see Nomenclature conflict Note)
Systematic Name	YHR102W
Alias	NRK1
Feature Type	ORF, Verified
Description	Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis (1, 2)
Name Description	Kinase that Interacts with Cdc31p 1

Chromosomal Location	ChrVIII:316572 to 319814 | ORF Map | GBrowse

	View Computational GO annotations for KIC1
Molecular Function
Manually curated	kinase activity (IDA, ISS)
Biological Process
Manually curated	budding cell apical bud growth (IGI, IMP) cell morphogenesis (IGI, IMP) fungal-type cell wall organization (IGI, IMP)
Cellular Component
Manually curated	cellular bud (IDA) incipient cellular bud site (IDA) mating projection tip (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	CTS1 mRNA accumulation: decreased actin cytoskeleton morphology: abnormal axial budding pattern: decreased bipolar budding pattern: decreased cell shape: abnormal colony appearance: abnormal liquid culture appearance: abnormal mating projection morphology: abnormal Cbk1p activity: decreased Hym1p-GFP distribution: abnormal Cbk1p-GFP distribution: abnormal Ace2p-GFP distribution: abnormal Mob2p-GFP distribution: abnormal
unspecified	transposable element transposition: decreased
Large-scale survey
null	filamentous growth: decreased invasive growth: absent
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	52 total interaction(s) for 32 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Affinity Capture-Western: 3 PCA: 2 Protein-RNA: 1 Two-hybrid: 8
Genetic Interactions	Dosage Rescue: 5 Phenotypic Enhancement: 5 Synthetic Growth Defect: 6 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:316572 to 319814 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3243 316572..319814 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001144