Standard Name	KGD1 1
Systematic Name	YIL125W
Alias	OGD1
Feature Type	ORF, Verified
Description	Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA (2)
Name Description	alpha-KetoGlutarate Dehydrogenase

Chromosomal Location	ChrIX:122689 to 125733 | ORF Map | GBrowse
	Genetic position: -91 cM

	View Computational GO annotations for KGD1
Molecular Function
Manually curated	oxoglutarate dehydrogenase (succinyl-transferring) activity (TAS)
Biological Process
Manually curated	2-oxoglutarate metabolic process (TAS) tricarboxylic acid cycle (TAS)
Cellular Component
Manually curated	mitochondrial nucleoid (IDA) mitochondrial oxoglutarate dehydrogenase complex (IDA)
High-throughput	mitochondrion (IDA)

Pathways	2-ketoglutarate dehydrogenase complex superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Classical genetics
null	respiratory growth: absent survival rate in stationary phase: decreased toxin resistance: decreased utilization of carbon source: absent
Large-scale survey
null	cell size: increased chronological lifespan: decreased competitive fitness: decreased dessication resistance: decreased haploproficient ionic stress resistance: decreased resistance to ethanol: decreased resistance to tirapazamine: increased resistance to quinine: decreased respiratory growth: absent respiratory growth: decreased respiratory growth: decreased rate sporulation efficiency: decreased stress resistance: decreased toxin resistance: decreased utilization of carbon source: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	59 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 41 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 2 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Growth Defect: 3 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:122689 to 125733 | ORF Map | GBrowse
	Genetic position: -91 cM
Last Update	Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3045 122689..125733 1994-12-10 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001387