KGD1/YIL125W Summary

KGD1 BASIC INFORMATION

Standard Name	KGD1 1
Systematic Name	YIL125W
Alias	OGD1
Feature Type	ORF, Verified
Description	Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA (2)
Name Description	alpha-KetoGlutarate Dehydrogenase

GO Annotations	All KGD1 GO evidence and references
	View Computational GO annotations for KGD1
Molecular Function
Manually curated	oxoglutarate dehydrogenase (succinyl-transferring) activity (TAS)
Biological Process
Manually curated	2-oxoglutarate metabolic process (TAS) tricarboxylic acid cycle (TAS)
Cellular Component
Manually curated	mitochondrial matrix (TAS) mitochondrial nucleoid (IDA) mitochondrial oxoglutarate dehydrogenase complex (IDA)
High-throughput	mitochondrion (IDA)

Pathways	2-ketoglutarate dehydrogenase complex superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Mutant Phenotype	All KGD1 Phenotype details and references
Classical genetics
null	respiratory growth: absent toxin resistance: decreased
Large-scale survey
null	competitive fitness: decreased resistance to ethanol: decreased respiratory growth: decreased rate respiratory growth: absent toxin resistance: decreased utilization of carbon source: decreased viable

Interactions	KGD1 All interactions details and references
	41 total interaction(s) for 32 unique genes/features.
Physical Interactions	Affinity Capture-MS: 33 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Two-hybrid: 1
Genetic Interactions	Phenotypic Suppression: 1 Synthetic Lethality: 4

Sequence Information

ChrIX:122689 to 125733 | |

Genetic position: -91 cM

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3045	122689..125733	1994-12-10	1994-12-10

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001387

KGD1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for KGD1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KGD1]

1)	Subik, J. (1992) Personal Communication, Mortimer Map Edition 11
2)	Repetto B and Tzagoloff A (1989) Structure and regulation of KGD1, the structural gene for yeast alpha-ketoglutarate dehydrogenase. Mol Cell Biol 9(6):2695-705

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