KEL1/YHR158C Summary

KEL1 BASIC INFORMATION

Standard Name	KEL1 1
Systematic Name	YHR158C
Feature Type	ORF, Verified
Description	Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate (1, 2)
Name Description	KELch repeat 1

GO Annotations	All KEL1 GO evidence and references
	View Computational GO annotations for KEL1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cell morphogenesis (TAS) cytogamy (IGI, IMP, IPI) negative regulation of exit from mitosis (IMP, IPI) plasma membrane fusion (TAS) regulation of cell shape (IMP)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) mating projection tip (IDA)
High-throughput	cytoplasm (IDA) mating projection tip (IDA)

Mutant Phenotype	All KEL1 Phenotype details and references
Classical genetics
overexpression	budding: abnormal cell cycle progression in G1 phase: abnormal cellular morphology: abnormal
Large-scale survey
null	bud morphology: abnormal filamentous growth: decreased invasive growth: absent viable
overexpression	vegetative growth: decreased

Interactions	KEL1 All interactions details and references
	57 total interaction(s) for 37 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Affinity Capture-Western: 5 Biochemical Activity: 4 PCA: 3 Two-hybrid: 15
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Synthetic Growth Defect: 4 Synthetic Rescue: 2

Sequence Information

ChrVIII:417182 to 413688 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3495	417182..413688	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001201

KEL1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for KEL1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KEL1]

1)	Philips J and Herskowitz I (1998) Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae. J Cell Biol 143(2):375-89
2)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64

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