KAR4/YCL055W Summary Help

Standard Name KAR4 1
Systematic Name YCL055W
Feature Type ORF, Verified
Description Transcription factor required for response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone (2, 3, 4)
Name Description KARyogamy
Chromosomal Location
ChrIII:27929 to 28936 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All KAR4 GO evidence and references
  View Computational GO annotations for KAR4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Targets 4 genes
Regulators 6 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
32 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • PCA: 2
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 18
  • Phenotypic Suppression: 1
  • Positive Genetic: 4
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 335
Molecular Weight (Da) 38,672
Isoelectric Point (pI) 8.61
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:27929 to 28936 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2000-09-13 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1008 27929..28936 2000-09-13 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000560
References cited on this page View Complete Literature Guide for KAR4
1) Kurihara LJ, et al.  (1994) Nuclear congression and membrane fusion: two distinct events in the yeast karyogamy pathway. J Cell Biol 126(4):911-23
2) Kurihara LJ, et al.  (1996) Kar4p, a karyogamy-specific component of the yeast pheromone response pathway. Mol Cell Biol 16(8):3990-4002
3) Gammie AE, et al.  (1999) The two forms of karyogamy transcription factor Kar4p are regulated by differential initiation of transcription, translation, and protein turnover. Mol Cell Biol 19(1):817-25
4) Lahav R, et al.  (2007) Role of transcription factor Kar4 in regulating downstream events in the Saccharomyces cerevisiae pheromone response pathway. Mol Cell Biol 27(3):818-29