Standard Name	KAP122
Systematic Name	YGL016W
Alias	PDR6
Feature Type	ORF, Verified
Description	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance (1, 2)
Name Description	KAryoPherin

Chromosomal Location	ChrVII:461666 to 464911 | ORF Map | GBrowse
	Genetic position: -10 cM

	View Computational GO annotations for KAP122
Molecular Function
Manually curated	protein transporter activity (IMP, IPI)
Biological Process
Manually curated	protein import into nucleus (IDA, IMP)
High-throughput	regulation of cell size (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nuclear pore (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	Rnr4p distribution: abnormal
Large-scale survey
null	cell size: decreased competitive fitness: decreased endocytosis: decreased haploinsufficient hyperosmotic stress resistance: decreased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to sodium selenide: decreased resistance to ethanol: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	94 total interaction(s) for 87 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-Western: 6 Co-localization: 4 Co-purification: 1 Reconstituted Complex: 3 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 45 Phenotypic Enhancement: 4 Positive Genetic: 8 Synthetic Growth Defect: 4 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:461666 to 464911 | ORF Map | GBrowse
	Genetic position: -10 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3246 461666..464911 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002984