Standard Name	KAP120
Systematic Name	YPL125W
Alias	LPH2 1
Feature Type	ORF, Verified
Description	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p (2, 3)
Name Description	KAryoPherin

Chromosomal Location	ChrXVI:313388 to 316486 | ORF Map | GBrowse

	View Computational GO annotations for KAP120
Molecular Function
Manually curated	protein transporter activity (IDA, IMP) structural constituent of nuclear pore (IPI)
Biological Process
Manually curated	protein import into nucleus (IMP, IPI) transcription factor import into nucleus (IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IDA) nuclear pore (IDA) nucleus (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
dominant negative	inviable
null	actin cytoskeleton morphology: abnormal endocytosis: decreased
Large-scale survey
null	budding index: decreased cell cycle progression in G1 phase: increased duration polyphosphate accumulation: abnormal competitive fitness: decreased fermentative growth: decreased rate heat sensitivity: increased resistance to hygromycin B: decreased resistance to sodium arsenite: increased stress resistance: increased toxin resistance: increased transposable element transposition: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	101 total interaction(s) for 78 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-Western: 1 Co-purification: 1 Protein-RNA: 1 Reconstituted Complex: 6 Two-hybrid: 12
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 23 Phenotypic Enhancement: 7 Phenotypic Suppression: 7 Positive Genetic: 33 Synthetic Growth Defect: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:313388 to 316486 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3099 313388..316486 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006046