KAP104/YBR017C Summary

KAP104 BASIC INFORMATION

Standard Name	KAP104
Systematic Name	YBR017C
Feature Type	ORF, Verified
Description	Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis (1, 2, 3, 4)
Name Description	KAryoPherin

GO Annotations	All KAP104 GO evidence and references
	View Computational GO annotations for KAP104
Molecular Function
Manually curated	nuclear localization sequence binding (IPI)
Biological Process
Manually curated	cell cycle (IMP) mRNA-binding (hnRNP) protein import into nucleus (IDA, IMP, IPI, ISS) protein import into nucleus (IDA, IMP, IPI, ISS) transcription factor import into nucleus (IMP, IPI)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) cytosol (IDA)

Mutant Phenotype	All KAP104 Phenotype details and references
Classical genetics
conditional	GFP-GST-Tfg2p PY-NLS distribution: abnormal
null	Hrp1p distribution: abnormal Nab2p distribution: abnormal
Large-scale survey
null	viable

Interactions	KAP104 All interactions details and references
	119 total interaction(s) for 76 unique genes/features.
Physical Interactions	Affinity Capture-MS: 72 Affinity Capture-Western: 11 Co-localization: 1 Co-purification: 1 Protein-peptide: 2 Reconstituted Complex: 17 Two-hybrid: 8
Genetic Interactions	Synthetic Growth Defect: 1 Synthetic Lethality: 1 Synthetic Rescue: 5

Sequence Information

ChrII:273703 to 270947 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2757	273703..270947	2004-07-16	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000221

KAP104 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for KAP104

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KAP104]

1)	Lee DC and Aitchison JD (1999) Kap104p-mediated nuclear import. Nuclear localization signals in mRNA-binding proteins and the role of Ran and Rna. J Biol Chem 274(41):29031-7
2)	Aitchison JD, et al. (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7
3)	Seedorf M and Silver PA (1997) Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc Natl Acad Sci U S A 94(16):8590-5
4)	van den Bogaart G, et al. (2009) Nuclear transport factor directs localization of protein synthesis during mitosis. Nat Cell Biol 11(3):350-6

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