Standard Name	KAE1 1
Systematic Name	YKR038C
Feature Type	ORF, Verified
Description	Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription (1, 2, 3, 4, 5, 6)
Name Description	Kinase-Associated Endopeptidase 1

Chromosomal Location	ChrXI:513159 to 511999 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for KAE1
Molecular Function
Manually curated	chromatin DNA binding (IDA)
Biological Process
Manually curated	chromosome organization (IMP) positive regulation of transcription from RNA polymerase II promoter (IPI) telomere maintenance (IPI) threonylcarbamoyladenosine metabolic process (IMP)
Cellular Component
Manually curated	EKC/KEOPS complex (IDA) colocalizes_with nuclear chromatin (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
conditional	colony sectoring: increased
null	tRNA-Ile modification: absent telomere length: decreased viable
reduction of function	tRNA-Ile modification: absent
unspecified	inviable
Large-scale survey
conditional	heat sensitivity: increased
null	haploinsufficient inviable vegetative growth: normal
reduction of function	competitive fitness: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	53 total interaction(s) for 26 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-RNA: 3 Affinity Capture-Western: 2 Biochemical Activity: 1 Far Western: 3 PCA: 1 Reconstituted Complex: 3 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 9 Phenotypic Suppression: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:513159 to 511999 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1161 513159..511999 2011-02-03 2003-09-22
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001746