Search results for Locus Summary pages at SGD

Your query, K1, returned 85 hits to the following gene names:

Match Gene Name Systematic Name Alias(es) Reserved Gene Name Position Info Description
ACK1 ACK1 YDL203C

ChrIV:97953 to 96082 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1872 97953..96082

Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria

ADK1 ADK1 YDR226W AKY1, AKY2, adenylate kinase ADK1

ChrIV:916486 to 917154 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..669 916486..917154

Genetic position: 133 cM

Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress

ALK1 ALK1 YGL021W protein kinase ALK1

ChrVII:454785 to 457067 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2283 454785..457067

Protein kinase; along with its paralog, ALK2, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of cell polarity factors in mitosis, proper localization of formins and polarity factors, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins

ARK1 ARK1 YNL020C serine/threonine protein kinase ARK1

ChrXIV:597539 to 595623 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1917 597539..595623

Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication

ASK1 ASK1 YKL052C

ChrXI:340546 to 339668 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..879 340546..339668

Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; sumoylated in an Mms21p-dependent manner; protein abundance increases in response to DNA replication stress

ASK10 ASK10 YGR097W RGC2

ChrVII:678695 to 682135 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..3441 678695..682135

Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication

BCK1 BCK1 YJL095W LAS3, SAP3, SLK1, SSP31, mitogen-activated protein kinase kinase kinase BCK1

ChrX:247255 to 251691 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..4437 247255..251691

Genetic position: -64 cM

MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase

BIK1 BIK1 YCL029C ARM5, PAC14

ChrIII:69921 to 68599 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1323 69921..68599

Genetic position: -21 cM

Microtubule-associated protein; component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170

CAK1 CAK1 YFL029C CIV1, cyclin-dependent protein kinase-activating kinase CAK1

ChrVI:79161 to 78055 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1107 79161..78055

Cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases

CBK1 CBK1 YNL161W serine/threonine protein kinase CBK1

ChrXIV:332597 to 334867 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2271 332597..334867

Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress

CDK1 CDC28 YBR160W CDK1, HSL5, SRM5, cyclin-dependent serine/threonine-protein kinase CDC28

ChrII:560078 to 560974 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..897 560078..560974

Genetic position: 90 cM

Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1 (CLNs), S and G2/M (CLBs) phase cyclins, which provide substrate specificity; regulates cell cycle and basal transcription, chromosome duplication and segregation, lipid biosynthesis, membrane trafficking, polarized growth, and morphogenesis; abundance increases in DNA replication stress; transcript induction in osmostress involves antisense RNA

CHK1 CHK1 YBR274W serine/threonine protein kinase CHK1

ChrII:749594 to 751177 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1584 749594..751177

Serine/threonine kinase and DNA damage checkpoint effector; mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase

CIK1 CIK1 YMR198W

ChrXIII:659745 to 661529 | ORF Map | GBrowse

Relative
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Chromosomal
Coordinates
CDS 1..1785 659745..661529

Kinesin-associated protein; required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; locus encodes a long and short transcript with differing functions; CIK1 has a paralog, VIK1, that arose from the whole genome duplication

CLK1 RCK2 YLR248W CLK1, CMK3, serine/threonine protein kinase RCK2

ChrXII:634252 to 636084 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1833 634252..636084

Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication

CMK1 CMK1 YFR014C calmodulin-dependent protein kinase CMK1

ChrVI:173877 to 172537 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1341 173877..172537

Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication

CTK1 CTK1 YKL139W cyclin-dependent serine/threonine protein kinase CTK1

ChrXI:182958 to 184544 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1587 182958..184544

Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13

CYK1 IQG1 YPL242C CYK1

ChrXVI:95109 to 90622 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..4488 95109..90622

Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress

DAK1 DAK1 YML070W

ChrXIII:133475 to 135229 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1755 133475..135229

Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation

DCK1 YLR422W DCK1

ChrXII:965897 to 971695 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..5799 965897..971695

Protein of unknown function with similarity to human DOCK proteins; interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein; DOCK proteins act as guanine nucleotide exchange factors

DGK1 DGK1 YOR311C HSD1

ChrXV:899928 to 899056 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..873 899928..899056

Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain

DSK1 CDC31 YOR257W DSK1, centrin

ChrXV:811008 to 811493 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..486 811008..811493

Genetic position: 147 cM

Calcium-binding component of the spindle pole body (SPB) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation

FLK1 TUP1 YCR084C AAR1, AER2, AMM1, CRT4, CYC9, FLK1, ROX4, SFL2, UMR7

ChrIII:262452 to 260311 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2142 262452..260311

Genetic position: 77 cM

General repressor of transcription; forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes

FPK1 FPK1 YNR047W serine/threonine protein kinase FPK1

ChrXIV:708523 to 711204 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2682 708523..711204

Ser/Thr protein kinase; regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane; FPK1 has a paralog, KIN82, that arose from the whole genome duplication

FRK1 FRK1 YPL141C protein kinase FRK1

ChrXVI:286061 to 283464 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2598 286061..283464

Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication

GLK1 GLK1 YCL040W HOR3, glucokinase

ChrIII:50838 to 52340 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1503 50838..52340

Genetic position: -47 cM

Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication

GUK1 GUK1 YDR454C PUR5, guanylate kinase

ChrIV:1366827 to 1366264 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..564 1366827..1366264

Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins

HEK1 PBP2 YBR233W HEK1

ChrII:683428 to 684669 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1242 683428..684669

RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress

HRK1 HRK1 YOR267C putative serine/threonine protein kinase HRK1

ChrXV:824867 to 822588 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2280 824867..822588

Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress

HSK1 DAD2 YKR083C HSK1

ChrXI:596822 to 596421 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..402 596822..596421

Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis

HXK1 HXK1 YFR053C hexokinase 1

ChrVI:255049 to 253592 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1458 255049..253592

Genetic position: 70 cM

Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication

IPK1 IPK1 YDR315C GSL1, inositol pentakisphosphate 2-kinase

ChrIV:1093586 to 1092741 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..846 1093586..1092741

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase; nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable

MAK1
MAK17
TOP1 YOL006C MAK1, MAK17, DNA topoisomerase 1

ChrXV:315387 to 313078 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2310 315387..313078

Genetic position: 3 cM

Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks

MAK10 MAK10 YEL053C NAA35

ChrV:56102 to 53901 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2202 56102..53901

Genetic position: -43 cM

Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; expression is glucose-repressible

MAK11 MAK11 YKL021C

ChrXI:398750 to 397344 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1407 398750..397344

Genetic position: -16 cM

Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats

MAK16 MAK16 YAL025C ribosome biosynthesis protein MAK16

ChrI:101145 to 100225 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..921 101145..100225

Genetic position: -31 cM

Essential nuclear protein; constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus

MAK18 RPL42B YHR141C MAK18, L41B, L42B, YL27, YP44, L44e, ribosomal 60S subunit protein L42B

ChrVIII:382751 to 381990 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..4 382751..382748
Intron 5..445 382747..382307
CDS 446..762 382306..381990

Genetic position: 95 cM

Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication

MCK1 MCK1 YNL307C YPK1, CMS1, serine/threonine/tyrosine protein kinase MCK1

ChrXIV:57573 to 56446 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1128 57573..56446

Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p and Cdc6p), inhibition of protein kinase A, transcriptional regulation, inhibition of RNA pol III, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog, YGK3, that arose from the whole genome duplication

MEK1 MEK1 YOR351C MRE4, serine/threonine protein kinase MEK1

ChrXV:996511 to 995018 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1494 996511..995018

Genetic position: 175 cM

Meiosis-specific serine/threonine protein kinase; functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids; stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during meiosis

MKK1 MKK1 YOR231W SSP32, mitogen-activated protein kinase kinase MKK1

ChrXV:772601 to 774127 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1527 772601..774127

MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication

MPK1 SLT2 YHR030C BYC2, MPK1, SLK2, LYT2, mitogen-activated serine/threonine-protein kinase SLT2

ChrVIII:170344 to 168890 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1455 170344..168890

Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, cell cycle progression, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to phagophore assembly site (PAS); plays a role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway; SLT2 has a paralog, KDX1, that arose from the whole genome duplication

MRK1 MRK1 YDL079C putative serine/threonine protein kinase MRK1

ChrIV:314748 to 312951 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..412 314748..314337
Intron 413..704 314336..314045
CDS 705..1798 314044..312951

Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication

MSK1 MSK1 YNL073W lysine--tRNA ligase MSK1

ChrXIV:488386 to 490116 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1731 488386..490116

Mitochondrial lysine-tRNA synthetase; required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)

MUK1 MUK1 YPL070W guanine nucleotide exchange factor MUK1

ChrXVI:420948 to 422786 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1839 420948..422786

Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain

NIK1 HSL1 YKL101W NIK1, ELM2, protein kinase HSL1

ChrXI:248920 to 253476 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..4557 248920..253476

Nim1p-related protein kinase; regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p

NNK1 NNK1 YKL171W protein kinase NNK1

ChrXI:127475 to 130261 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2787 127475..130261

Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm

NPK1 KIN3 YAR018C FUN52, NPK1, serine/threonine protein kinase KIN3

ChrI:171703 to 170396 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1308 171703..170396

Nonessential serine/threonine protein kinase; possible role in DNA damage response; influences tolerance to high levels of ethanol

NRK1 KIC1 YHR102W NRK1, putative serine/threonine protein kinase KIC1

ChrVIII:316572 to 319814 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..3243 316572..319814

Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis

NRK1 NRK1 YNL129W ribosylnicotinamide kinase

ChrXIV:381480 to 382202 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..723 381480..382202

Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis

PCK1 PCK1 YKR097W JPM2, PPC1, phosphoenolpyruvate carboxykinase PCK1

ChrXI:631152 to 632801 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1650 631152..632801

Genetic position: 73.2 cM

Phosphoenolpyruvate carboxykinase; key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol

PFK1 PFK1 YGR240C 6-phosphofructokinase subunit alpha

ChrVII:973734 to 970771 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2964 973734..970771

Genetic position: 184 cM

Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes

PGK1 PGK1 YCR012W phosphoglycerate kinase

ChrIII:137746 to 138996 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1251 137746..138996

Genetic position: 2 cM

3-phosphoglycerate kinase; catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis

PIK1 PIK1 YNL267W PIK41, PIK120, 1-phosphatidylinositol 4-kinase

ChrXIV:140878 to 144078 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..3201 140878..144078

Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; may control nonselective autophagy and mitophagy through trafficking of Atg9p

PRK1 PRK1 YIL095W PAK1, serine/threonine protein kinase PRK1

ChrIX:183937 to 186369 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2433 183937..186369

Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication

PSK1 PSK1 YAL017W FUN31, serine/threonine protein kinase PSK1

ChrI:120225 to 124295 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..4071 120225..124295

PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication

PTK1 PTK1 YKL198C KKT8, STK1, YKL199C, YKT9, POT1, putative serine/threonine protein kinase PTK1

ChrXI:70220 to 68232 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1989 70220..68232

Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog, PTK2, that arose from the whole genome duplication

PYK1 CDC19 YAL038W PYK1, pyruvate kinase CDC19

ChrI:71786 to 73288 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1503 71786..73288

Genetic position: -45 cM

Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication

RBK1 RBK1 YCR036W

ChrIII:193297 to 194298 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1002 193297..194298

Genetic position: 29 cM

Putative ribokinase

RCK1 RCK1 YGL158W putative serine/threonine protein kinase RCK1

ChrVII:207033 to 208571 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1539 207033..208571

Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication

RHK1 ALG3 YBL082C RHK1, dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase

ChrII:71127 to 69751 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1377 71127..69751

Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins

ROK1 ROK1 YGL171W RNA-dependent ATPase ROK1

ChrVII:182390 to 184084 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1695 182390..184084

RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation

RPK1 MPS1 YDL028C RPK1, PAC8, serine/threonine/tyrosine protein kinase MPS1

ChrIV:403291 to 400997 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2295 403291..400997

Dual-specificity kinase; autophosphorylation required for function; required for spindle pole body (SPB) duplication and spindle checkpoint function; contributes to bi-orientation by promoting formation of force-generating kinetochore-microtubule attachments in meiosis I; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p; substrate of APCC(Cdh1); similar to human Mps1p

RTK1 RTK1 YDL025C putative serine/threonine protein kinase RTK1

ChrIV:407206 to 405344 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1863 407206..405344

Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress

SAK1 SAK1 YER129W PAK1, serine/threonine protein kinase SAK1

ChrV:417281 to 420709 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..3429 417281..420709

Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal groth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog, TOS3, that arose from the whole genome duplication

SFK1 SFK1 YKL051W

ChrXI:341312 to 342373 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1062 341312..342373

Plasma membrane protein that may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane

SIK1 NOP56 YLR197W SIK1, snoRNP complex protein NOP56

ChrXII:546097 to 547611 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1515 546097..547611

Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects

SLK19 SLK19 YOR195W

ChrXV:712866 to 715331 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2466 712866..715331

Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate

SMK1 SMK1 YPR054W mitogen-activated protein kinase SMK1

ChrXVI:666280 to 667446 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1167 666280..667446

Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p

SOK1 SOK1 YDR006C

ChrIV:461247 to 458542 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2706 461247..458542

Protein of unknown function; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13

SPK1 RAD53 YPL153C LSD1, MEC2, SPK1, serine/threonine/tyrosine protein kinase RAD53

ChrXVI:264192 to 261727 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2466 264192..261727

Genetic position: -109 cM

DNA damage response protein kinase; required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication; activates the downstream kinase Dun1p; differentially senses mtDNA depletion and mitochondrial ROS; required for regulation of copper genes in response to DNA-damaging agents; relocalizes to cytosol in response to hyoxia

SRK1 SSD1 YDR293C CLA1, MCS1, RLT1, SRK1

ChrIV:1049392 to 1045640 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..3753 1049392..1045640

Genetic position: 176 cM

Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function

SSK1 SSK1 YLR006C mitogen-activated protein kinase kinase kinase SSK1

ChrXII:163893 to 161755 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2139 163893..161755

Cytoplasmic phosphorelay intermediate osmosensor and regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate

tA(AGC)K1 tA(AGC)K1

ChrXI:219895 to 219967 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..73 219895..219967

Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon AGC (converted to IGC in the mature tRNA), decodes GCU and GCC codons into alanine, one of 16 nuclear tRNAs for alanine

TAK1 RIM15 YFL033C TAK1, protein kinase RIM15

ChrVI:74427 to 69115 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..5313 74427..69115

Protein kinase involved in cell proliferation in response to nutrients; glucose-repressible; involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; phosphorylates Igo1p and Igo2p; substrate of Pho80p-Pho85p kinase

TOK1 TOK1 YJL093C DUK1, YKC1, YORK, YPK1

ChrX:256812 to 254737 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2076 256812..254737

Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin

TPK1 TPK1 YJL164C PKA1, SRA3, cAMP-dependent protein kinase catalytic subunit TPK1

ChrX:111159 to 109966 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1194 111159..109966

Genetic position: -106 cM

cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication

TRK1 TRK1 YJL129C

ChrX:177306 to 173599 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..3708 177306..173599

Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication

tV(AAC)K1 tV(AAC)K1

ChrXI:308217 to 308144 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
Noncoding exon 1..74 308217..308144

Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis

URK1 URK1 YNR012W uridine kinase URK1

ChrXIV:647432 to 648937 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1506 647432..648937

Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP

VIK1 VIK1 YPL253C

ChrXVI:73006 to 71063 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1944 73006..71063

Protein that forms a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor domain but lacks an ATP-binding site and is catalytically inactive; binds microtubules; required for sister chromatid cohesion; VIK1 has a paralog, CIK1, that arose from the whole genome duplication

YAK1 YAK1 YJL141C serine/threonine protein kinase YAK1

ChrX:150390 to 147967 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2424 150390..147967

Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose

YCK1 YCK1 YHR135C CKI2, serine/threonine protein kinase YCK1

ChrVIII:374310 to 372694 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1617 374310..372694

Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; YCK1 has a paralog, YCK2, that arose from the whole genome duplication

YK105 MRPL13 YKR006C YK105, YmL13, mitochondrial 54S ribosomal protein YmL13

ChrXI:451217 to 450423 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..795 451217..450423

Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation

YMK1 MLF3 YNL074C YMK1

ChrXIV:488124 to 486766 | ORF Map | GBrowse

Note: this feature is encoded on the Crick strand.

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..1359 488124..486766

Serine-rich protein of unknown function; predicted to be palmitoylated; overproduction suppresses growth inhibition caused by exposure to immunosuppressant leflunomide; MLF3 has a paralog, VHS2, that arose from the whole genome duplication

YNK1 YNK1 YKL067W NDK1, nucleoside diphosphate kinase

ChrXI:314812 to 315273 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..462 314812..315273

Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress

YPK1 YPK1 YKL126W SLI2, serine/threonine protein kinase YPK1

ChrXI:205707 to 207749 | ORF Map | GBrowse

Relative
Coordinates
Chromosomal
Coordinates
CDS 1..2043 205707..207749

Genetic position: -97.7 cM

Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication