JIP5/YPR169W Summary Help

Standard Name JIP5 1
Systematic Name YPR169W
Feature Type ORF, Verified
Description Protein required for biogenesis of the large ribosomal subunit; required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein; essential gene (2, 3, 4, 5, 6, 7, 8)
Name Description Jumonji domain Interacting Protein 1
Chromosomal Location
ChrXVI:878690 to 880168 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All JIP5 GO evidence and references
  View Computational GO annotations for JIP5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 4 genes
Resources
Classical genetics
repressible
Large-scale survey
conditional
null
overexpression
reduction of function
repressible
Resources
25 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 492
Molecular Weight (Da) 55,264
Isoelectric Point (pI) 4.89
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:878690 to 880168 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2005-12-01
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1479 878690..880168 2011-02-03 2005-12-01
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006373
References cited on this page View Complete Literature Guide for JIP5
1) Tronnersjo S, et al.  (2007) The jmjN and jmjC domains of the yeast zinc finger protein Gis1 interact with 19 proteins involved in transcription, sumoylation and DNA repair. Mol Genet Genomics 277(1):57-70
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Hazbun TR, et al.  (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65
4) Graumann J, et al.  (2004) Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast. Mol Cell Proteomics 3(3):226-37
5) Krogan NJ, et al.  (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440(7084):637-43
6) Perocchi F, et al.  (2006) Assessing Systems Properties of Yeast Mitochondria through an Interaction Map of the Organelle. PLoS Genet 2(10):e170
7) Oeffinger M, et al.  (2007) Comprehensive analysis of diverse ribonucleoprotein complexes. Nat Methods 4(11):951-6
8) Li Z, et al.  (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213