JHD2/YJR119C Summary Help

Standard Name JHD2 1, 2
Systematic Name YJR119C
Alias KDM5 3
Feature Type ORF, Verified
Description JmjC domain family histone demethylase; promotes global demethylation of H3K4 and repression of noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p methyltransferase; negatively regulated by H3K14 acetylation; protein levels regulated by Not4p polyubiquitin-mediated degradation; regulates spore differentiation timing by extending period of active transcription in opposition to programmed global transcriptional quiescence (1, 2, 4, 5, 6, 7)
Name Description JmjC domain-containing Histone Demethylase 1, 2
Gene Product Alias KDM5 3
Chromosomal Location
ChrX:646490 to 644304 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All JHD2 GO evidence and references
  View Computational GO annotations for JHD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Regulators 7 genes
Classical genetics
Large-scale survey
63 total interaction(s) for 56 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 6
  • Co-localization: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 42
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 728
Molecular Weight (Da) 84,983
Isoelectric Point (pI) 6.1
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrX:646490 to 644304 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2187 646490..644304 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003880
References cited on this page View Complete Literature Guide for JHD2
1) Liang G, et al.  (2007) Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. Nat Struct Mol Biol 14(3):243-5
2) Tu S, et al.  (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71
3) Ingvarsdottir K, et al.  (2007) Histone H3 K4 Demethylation during Activation and Attenuation of GAL1 Transcription in Saccharomyces cerevisiae. Mol Cell Biol 27(22):7856-64
4) Seward DJ, et al.  (2007) Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol 14(3):240-2
5) Mersman DP, et al.  (2009) Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev 23(8):951-62
6) Maltby VE, et al.  (2012) Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 109(45):18505-10
7) Xu M, et al.  (2012) Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation. Dev Cell 23(5):1059-71