Standard Name	ITC1 1
Systematic Name	YGL133W
Feature Type	ORF, Verified
Description	Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex; ITC1 has a paralog, YPL216W, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	Imitation switch Two Complex 6

Chromosomal Location	ChrVII:257707 to 261501 | ORF Map | GBrowse

	View Computational GO annotations for ITC1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromatin remodeling (TAS) chromatin silencing at telomere (IMP) negative regulation of transcription from RNA polymerase II promoter by pheromones (IMP)
Cellular Component
Manually curated	CHRAC (IPI)
High-throughput	nucleus (IDA)

Classical genetics
null	cell shape: abnormal invasive growth: increased mating efficiency: decreased Slt2p modification: increased
Large-scale survey
null	competitive fitness: decreased haploinsufficient oxidative stress resistance: decreased resistance to cycloheximide: decreased resistance to camptothecin: increased resistance to bleomycin: increased resistance to fenpropimorph: decreased resistance to caffeine: decreased resistance to tunicamycin: decreased resistance to fluconazole: decreased transposable element transposition: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	190 total interaction(s) for 141 unique genes/features.
Physical Interactions	Affinity Capture-MS: 42 Affinity Capture-RNA: 2 Affinity Capture-Western: 5 Co-localization: 2 PCA: 4 Reconstituted Complex: 1 Two-hybrid: 9
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 96 Phenotypic Enhancement: 1 Positive Genetic: 15 Synthetic Growth Defect: 7 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:257707 to 261501 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3795 257707..261501 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003101