Standard Name	ISW2
Systematic Name	YOR304W
Feature Type	ORF, Verified
Description	ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth (1, 2, 3, 4)
Name Description	Imitation SWitch subfamily 1

Chromosomal Location	ChrXV:884514 to 887876 | ORF Map | GBrowse

	View Computational GO annotations for ISW2
Molecular Function
Manually curated	DNA translocase activity (IDA) single-stranded DNA binding (IDA)
Biological Process
Manually curated	chromatin remodeling (IGI, IMP, IPI) chromatin silencing at rDNA (IMP) NOT chromatin silencing at telomere (IMP) chromatin silencing at telomere (IMP) negative regulation of antisense RNA transcription (IGI) negative regulation of transcription from RNA polymerase II promoter by pheromones (IMP) nucleosome positioning (IDA) termination of RNA polymerase II transcription (IGI)
Cellular Component
Manually curated	CHRAC (IPI, ISS) nucleus (IPI)
High-throughput	nucleus (IDA)

Classical genetics
null	cell shape: abnormal heat sensitivity: normal invasive growth: increased resistance to L-1,4-dithiothreitol: decreased resistance to mercaptoethanol: decreased resistance to tunicamycin: normal viable
Large-scale survey
null	competitive fitness: decreased resistance to fluconazole: increased resistance to amitrole: decreased resistance to hydroxyurea: decreased resistance to camptothecin: decreased resistance to sodium arsenite: decreased resistance to fenpropimorph: increased resistance to cycloheximide: decreased toxin resistance: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	323 total interaction(s) for 218 unique genes/features.
Physical Interactions	Affinity Capture-MS: 58 Affinity Capture-RNA: 2 Affinity Capture-Western: 8 Co-crystal Structure: 1 Co-localization: 5 Reconstituted Complex: 2
Genetic Interactions	Negative Genetic: 179 Phenotypic Enhancement: 10 Phenotypic Suppression: 3 Positive Genetic: 22 Synthetic Growth Defect: 27 Synthetic Lethality: 1 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:884514 to 887876 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3363 884514..887876 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005831