IST1/YNL265C Summary Help

Standard Name IST1 1
Systematic Name YNL265C
Feature Type ORF, Verified
Description Protein with positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p (2, 3)
Name Description Increased Sodium Tolerance 1
Chromosomal Location
ChrXIV:145281 to 144280 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All IST1 GO evidence and references
  View Computational GO annotations for IST1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
43 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 17
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Co-crystal Structure: 1
  • Co-localization: 4
  • Co-purification: 1
  • PCA: 3
  • Reconstituted Complex: 3

Genetic Interactions
  • Dosage Growth Defect: 2
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 298
Molecular Weight (Da) 34,495
Isoelectric Point (pI) 5.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:145281 to 144280 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..27 145281..145255 2011-02-03 1996-07-31
Intron 28..132 145254..145150 2011-02-03 1996-07-31
CDS 133..1002 145149..144280 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005209
References cited on this page View Complete Literature Guide for IST1
1) Entian KD, et al.  (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
2) Samanta MP and Liang S  (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
3) Rue SM, et al.  (2008) Novel ist1-did2 complex functions at a late step in multivesicular body sorting. Mol Biol Cell 19(2):475-84