ISR1/YPR106W Summary Help

Standard Name ISR1 1
Systematic Name YPR106W
Feature Type ORF, Verified
Description Predicted protein kinase; overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C (1)
Name Description Inhibition of Staurosporine Resistance 1
Chromosomal Location
ChrXVI:740061 to 741392 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ISR1 GO evidence and references
  View Computational GO annotations for ISR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
Resources
93 total interaction(s) for 87 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • PCA: 1
  • Reconstituted Complex: 20
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 6
  • Negative Genetic: 31
  • Phenotypic Suppression: 1
  • Positive Genetic: 8
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 443
Molecular Weight (Da) 49,735
Isoelectric Point (pI) 6.91
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:740061 to 741392 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1332 740061..741392 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006310
References cited on this page View Complete Literature Guide for ISR1
1) Miyahara K, et al.  (1998) Functional interaction of Isr1, a predicted protein kinase, with the Pkc1 pathway in Saccharomyces cerevisiae. Biosci Biotechnol Biochem 62(7):1376-80