ISD11/YER048W-A Summary Help

Standard Name ISD11 1, 2
Systematic Name YER048W-A
Feature Type ORF, Verified
Description Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster (ISC) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family (1, 2, 3, 4)
Name Description Iron-Sulfur protein biogenesis, Desulfurase-interacting protein 2
Chromosomal Location
ChrV:250718 to 251002 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ISD11 GO evidence and references
  View Computational GO annotations for ISD11
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
overexpression
reduction of function
Resources
20 total interaction(s) for 10 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Co-fractionation: 2
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 94
Molecular Weight (Da) 11,266
Isoelectric Point (pI) 11.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:250718 to 251002 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..285 250718..251002 2011-02-03 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007237
References cited on this page View Complete Literature Guide for ISD11
1) Adam AC, et al.  (2006) The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria. EMBO J 25(1):174-83
2) Wiedemann N, et al.  (2006) Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J 25(1):184-95
3) Terali K, et al.  (2013) The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1. Biochem Biophys Res Commun 440(2):235-40
4) Na U, et al.  (2014) The LYR Factors SDHAF1 and SDHAF3 Mediate Maturation of the Iron-Sulfur Subunit of Succinate Dehydrogenase. Cell Metab 20(2):253-66