Standard Name	ISD11 1, 2
Systematic Name	YER048W-A
Feature Type	ORF, Verified
Description	Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis (1, 2, 3)
Name Description	Iron-Sulfur protein biogenesis, Desulfurase-interacting protein 2

Chromosomal Location	ChrV:250718 to 251002 | ORF Map | GBrowse

	View Computational GO annotations for ISD11
Molecular Function
Manually curated	enzyme activator activity (IDA)
Biological Process
Manually curated	iron-sulfur cluster assembly (IMP, IPI)
Cellular Component
Manually curated	extrinsic to mitochondrial inner membrane (IDA) mitochondrial matrix (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
conditional	heat sensitivity: increased
null	inviable
Large-scale survey
null	haploinsufficient inviable
overexpression	vegetative growth: decreased
reduction of function	chromosome/plasmid maintenance: abnormal competitive fitness: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	20 total interaction(s) for 9 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-fractionation: 2 Reconstituted Complex: 2
Genetic Interactions	Dosage Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:250718 to 251002 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..285 250718..251002 2011-02-03 1999-07-17
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000007237