IRS4/YKR019C Summary Help

Standard Name IRS4 1
Systematic Name YKR019C
Feature Type ORF, Verified
Description EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Increased rDNA Silencing 1
Chromosomal Location
ChrXI:478063 to 476216 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All IRS4 GO evidence and references
  View Computational GO annotations for IRS4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
156 total interaction(s) for 115 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-Western: 1

Genetic Interactions
  • Negative Genetic: 128
  • Phenotypic Enhancement: 3
  • Positive Genetic: 11
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 615
Molecular Weight (Da) 68,879
Isoelectric Point (pI) 10.63
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:478063 to 476216 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1848 478063..476216 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001727
References cited on this page View Complete Literature Guide for IRS4
1) Smith JS, et al.  (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97
2) Paoluzi S, et al.  (1998) Recognition specificity of individual EH domains of mammals and yeast. EMBO J 17(22):6541-50
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Bugnicourt A, et al.  (2008) Irs4p and Tax4p: two redundant EH domain proteins involved in autophagy. Traffic 9(5):755-69