Standard Name	IRS4 1
Systematic Name	YKR019C
Feature Type	ORF, Verified
Description	EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Increased rDNA Silencing 1

Chromosomal Location	ChrXI:478063 to 476216 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for IRS4
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	autophagy (IGI) cellular response to starvation (IGI) chromatin silencing at rDNA (IMP) NOT CVT pathway (IGI) fungal-type cell wall organization (IGI) inositol lipid-mediated signaling (IGI)
Cellular Component
Manually curated	pre-autophagosomal structure (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	vegetative growth: decreased viable
Large-scale survey
null	polyphosphate accumulation: abnormal competitive fitness: decreased haploinsufficient heat sensitivity: increased metal resistance: decreased resistance to amitrole: decreased resistance to cycloheximide: decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to tunicamycin: decreased resistance to dimethyl sulfoxide: decreased resistance to mefloquine: decreased resistance to BPS: decreased resistance to hydroxyurea: increased resistance to hygromycin B: decreased sporulation: normal starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	152 total interaction(s) for 113 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 1
Genetic Interactions	Negative Genetic: 127 Phenotypic Enhancement: 3 Positive Genetic: 9 Synthetic Growth Defect: 9 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:478063 to 476216 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1848 478063..476216 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001727