Standard Name	IRC3 1
Systematic Name	YDR332W
Feature Type	ORF, Verified
Description	Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion (1, 2)
Name Description	Increased Recombination Centers 1

Chromosomal Location	ChrIV:1131001 to 1133070 | ORF Map | GBrowse

	View Computational GO annotations for IRC3
Molecular Function
Manually curated	ATP-dependent RNA helicase activity (ISS)
Biological Process
Manually curated	biological_process unknown (ND)
Cellular Component
High-throughput	mitochondrion (IDA)

Classical genetics
null	tellurium atom accumulation: decreased heat sensitivity: increased resistance to sirolimus: increased resistance to tellurite: increased vegetative growth: decreased viable
Large-scale survey
null	glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased Rad52-YFP distribution: increased resistance to bleomycin: increased resistance to camptothecin: increased resistance to caffeine: increased resistance to fenpropimorph: increased resistance to fluconazole: increased resistance to methyl methanesulfonate: increased resistance to mycophenolic acid: increased resistance to ethanol: decreased respiratory growth: absent respiratory growth: decreased rate stress resistance: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	58 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Two-hybrid: 7
Genetic Interactions	Negative Genetic: 19 Phenotypic Suppression: 1 Positive Genetic: 2 Synthetic Growth Defect: 9 Synthetic Lethality: 17
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1131001 to 1133070 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2070 1131001..1133070 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002740