IRC21/YMR073C Summary Help

Standard Name IRC21 1
Systematic Name YMR073C
Feature Type ORF, Verified
Description Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study (1, 2, 3)
Name Description Increased Recombination Centers 1
Chromosomal Location
ChrXIII:412873 to 412268 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All IRC21 GO evidence and references
  View Computational GO annotations for IRC21
Molecular Function
Manually curated
Biological Process
High-throughput
Cellular Component
High-throughput
Regulators 2 genes
Resources
Large-scale survey
null
overexpression
Resources
64 total interaction(s) for 53 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 23
  • Phenotypic Suppression: 14
  • Positive Genetic: 9
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 201
Molecular Weight (Da) 23,182
Isoelectric Point (pI) 10.29
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:412873 to 412268 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..606 412873..412268 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004677
References cited on this page View Complete Literature Guide for IRC21
1) Alvaro D, et al.  (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228
2) Lee W, et al.  (2005) Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. PLoS Genet 1(2):e24
3) Gallego O, et al.  (2010) A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Mol Syst Biol 6():430