IRC18/YJL037W Summary Help

Standard Name IRC18 1
Systematic Name YJL037W
Alias OSW6 2
Feature Type ORF, Verified
Description Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, LOH1/YJL038C, and the double mutant irc18 loh1 exhibits reduced dityrosine fluorescence relative to the single mutants; null mutant displays increased levels of spontaneous Rad52p foci (1, 2, 3, 4, 5, 6, 7)
Name Description Increased Recombination Centers 1
Chromosomal Location
ChrX:376662 to 377336 | ORF Map | GBrowse
Gene Ontology Annotations All IRC18 GO evidence and references
  View Computational GO annotations for IRC18
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Classical genetics
Large-scale survey
5 total interaction(s) for 5 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 2
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 224
Molecular Weight (Da) 24,746
Isoelectric Point (pI) 9.95
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrX:376662 to 377336 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..675 376662..377336 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003574
References cited on this page View Complete Literature Guide for IRC18
1) Alvaro D, et al.  (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228
2) Lin CP, et al.  (2013) A Highly Redundant Gene Network Controls Assembly of the Outer Spore Wall in S. cerevisiae. PLoS Genet 9(8):e1003700
3) Roberts CJ, et al.  (2000) Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287(5454):873-80
4) Chu S, et al.  (1998) The transcriptional program of sporulation in budding yeast. Science 282(5389):699-705
5) Primig M, et al.  (2000) The core meiotic transcriptome in budding yeasts. Nat Genet 26(4):415-23
6) Epstein CB, et al.  (2001) Genome-wide responses to mitochondrial dysfunction. Mol Biol Cell 12(2):297-308
7) Boer VM, et al.  (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74