IPP1/YBR011C Summary Help

Standard Name IPP1
Systematic Name YBR011C
Alias PPA1
Feature Type ORF, Verified
Description Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase (1, 2, 3)
Name Description Inorganic PyroPhosphatase
Chromosomal Location
ChrII:257975 to 257112 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All IPP1 GO evidence and references
  View Computational GO annotations for IPP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
conditional
null
reduction of function
Resources
100 total interaction(s) for 77 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 55
  • Affinity Capture-RNA: 4
  • PCA: 3
  • Protein-peptide: 5
  • Reconstituted Complex: 2

Genetic Interactions
  • Negative Genetic: 17
  • Positive Genetic: 8
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 287
Molecular Weight (Da) 32,299
Isoelectric Point (pI) 5.33
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:257975 to 257112 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..864 257975..257112 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000215
References cited on this page View Complete Literature Guide for IPP1
1) Lahti R, et al.  (1990) Conservation of functional residues between yeast and E. coli inorganic pyrophosphatases. Biochim Biophys Acta 1038(3):338-45
2) Kolakowski LF Jr, et al.  (1988) Cloning, molecular characterization and chromosome localization of the inorganic pyrophosphatase (PPA) gene from S. cerevisiae. Nucleic Acids Res 16(22):10441-52
3) Salminen A, et al.  (2002) Modulation of dimer stability in yeast pyrophosphatase by mutations at the subunit interface and ligand binding to the active site. J Biol Chem 277(18):15465-71