Standard Name	IPI1 1
Systematic Name	YHR085W
Feature Type	ORF, Verified
Description	Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene (1, 2, 3, 4)
Name Description	Involved in Processing ITS2 1

Chromosomal Location	ChrVIII:276764 to 277768 | ORF Map | GBrowse

	View Computational GO annotations for IPI1
Molecular Function
Manually curated	chromatin binding (IDA)
Biological Process
Manually curated	pre-replicative complex assembly (IMP) regulation of DNA-dependent DNA replication initiation (IMP) ribosomal large subunit assembly (IMP) rRNA processing (IMP)
Cellular Component
Manually curated	nucleoplasm (IDA) Rix1 complex (IDA)
High-throughput	nucleus (IDA)

Classical genetics
conditional	chromosome/plasmid maintenance: abnormal
null	dessication resistance: increased
repressible	mature 25S rRNA accumulation: decreased 20S pre-rRNA accumulation: decreased 35S pre-rRNA accumulation: increased 7S pre-rRNA accumulation: increased 27S pre-rRNA accumulation: increased mature 18S rRNA accumulation: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	inviable
reduction of function	chromosome/plasmid maintenance: abnormal competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	54 total interaction(s) for 28 unique genes/features.
Physical Interactions	Affinity Capture-MS: 41 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Co-fractionation: 2 Co-purification: 3
Genetic Interactions	Synthetic Growth Defect: 1 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:276764 to 277768 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1005 276764..277768 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001127