Standard Name	INO80 1
Systematic Name	YGL150C
Feature Type	ORF, Verified
Description	ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription (1, 2, 3, 4, 5)
Name Description	INOsitol requiring

Chromosomal Location	ChrVII:225573 to 221104 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for INO80
Molecular Function
Manually curated	contributes_to ATP-dependent 3'-5' DNA helicase activity (IDA) ATPase activity (IDA)
Biological Process
Manually curated	chromatin remodeling (IDA) chromatin silencing at telomere (IMP) DNA repair (IDA, IMP) histone exchange (IDA) nucleosome mobilization (IMP) nucleosome positioning (IDA) positive regulation of transcription from RNA polymerase II promoter (IMP) regulation of transcription from RNA polymerase II promoter in response to stress (IMP) transcription from RNA polymerase II promoter (IDA, IMP)
Cellular Component
Manually curated	Ino80 complex (IDA)

Classical genetics
null	UV resistance: decreased X ray resistance: increased auxotrophy resistance to methyl methanesulfonate: decreased utilization of carbon source: absent viable
Large-scale survey
null	haploinsufficient inviable resistance to sulfanilamide: decreased vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	188 total interaction(s) for 88 unique genes/features.
Physical Interactions	Affinity Capture-MS: 116 Affinity Capture-RNA: 1 Affinity Capture-Western: 14 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 37 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Positive Genetic: 2 Synthetic Growth Defect: 7 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:225573 to 221104 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4470 225573..221104 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003118