Standard Name	INN1 1
Systematic Name	YNL152W
Feature Type	ORF, Verified
Description	Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis (1, 2, 3, 4, 5, 6)
Name Description	required for INgressioN 1

Chromosomal Location	ChrXIV:346313 to 347542 | ORF Map | GBrowse

	View Computational GO annotations for INN1
Molecular Function
Manually curated	NOT phospholipid binding (IDA) phospholipid binding (ISS)
High-throughput	phospholipid binding (ISS)
Biological Process
Manually curated	barrier septum assembly (IGI, IMP) chromosome organization (IMP) cytokinesis (IGI, IMP, IPI) mitotic cytokinesis (IMP)
Cellular Component
Manually curated	cellular bud neck contractile ring (IDA) HICS complex (IPI)
High-throughput	cytoplasm (IDA)

Classical genetics
conditional	chromosome/plasmid maintenance: abnormal
null	cytokinesis: abnormal septum formation: absent vegetative growth: decreased
repressible	cytokinesis: absent
Large-scale survey
conditional	heat sensitivity: increased
null	inviable
overexpression	vegetative growth: decreased rate
reduction of function	resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	61 total interaction(s) for 18 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Affinity Capture-Western: 7 Biochemical Activity: 2 PCA: 6 Reconstituted Complex: 6 Two-hybrid: 22
Genetic Interactions	Dosage Rescue: 3 Synthetic Growth Defect: 5 Synthetic Lethality: 4 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:346313 to 347542 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1230 346313..347542 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005096