IME2/YJL106W Summary Help

Standard Name IME2 1
Systematic Name YJL106W
Alias SME1
Feature Type ORF, Verified
Description Serine/threonine protein kinase involved in activation of meiosis; associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p (2, 3)
Name Description Inducer of MEiosis 4
Chromosomal Location
ChrX:221390 to 223327 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All IME2 GO evidence and references
  View Computational GO annotations for IME2
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
overexpression
reduction of function
unspecified
Large-scale survey
null
overexpression
Resources
173 total interaction(s) for 154 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 71
  • Reconstituted Complex: 1
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Growth Defect: 5
  • Dosage Lethality: 1
  • Dosage Rescue: 6
  • Negative Genetic: 54
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 2
  • Positive Genetic: 4
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 645
Molecular Weight (Da) 73,592
Isoelectric Point (pI) 5.13
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:221390 to 223327 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1938 221390..223327 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003642
References cited on this page View Complete Literature Guide for IME2
1) Smith HE and Mitchell AP  (1989) A transcriptional cascade governs entry into meiosis in Saccharomyces cerevisiae. Mol Cell Biol 9(5):2142-52
2) Guttmann-Raviv N, et al.  (2002) Ime2, a meiosis-specific kinase in yeast, is required for destabilization of its transcriptional activator, Ime1. Mol Cell Biol 22(7):2047-56
3) Sopko R, et al.  (2002) Phosphorylation and maximal activity of Saccharomyces cerevisiae meiosis-specific transcription factor Ndt80 is dependent on Ime2. Mol Cell Biol 22(20):7024-40
4) Kassir Y, et al.  (1988) IME1, a positive regulator gene of meiosis in S. cerevisiae. Cell 52(6):853-62