IME1/YJR094C Summary

IME1 BASIC INFORMATION

Standard Name	IME1
Systematic Name	YJR094C
Feature Type	ORF, Verified
Description	Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p (1, 2)
Name Description	Inducer of MEiosis 3

GO Annotations	All IME1 GO evidence and references
	View Computational GO annotations for IME1
Molecular Function
Manually curated	transcription regulator activity (TAS)
Biological Process
Manually curated	meiosis (TAS)
Cellular Component
Manually curated	nucleus (IDA)

Mutant Phenotype	All IME1 Phenotype details and references
Classical genetics
overexpression	mitotic recombination: increased sporulation efficiency: increased
unspecified	sporulation: absent
Large-scale survey
null	resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to doxorubicin: decreased sporulation: absent viable

Interactions	IME1 All interactions details and references
	39 total interaction(s) for 22 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Biochemical Activity: 2 Two-hybrid: 10
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 12 Phenotypic Enhancement: 4 Phenotypic Suppression: 5

Sequence Information

ChrX:605643 to 604561 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1083	605643..604561	2009-02-18	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003854

IME1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for IME1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IME1]

1)	Guttmann-Raviv N, et al. (2002) Ime2, a meiosis-specific kinase in yeast, is required for destabilization of its transcriptional activator, Ime1. Mol Cell Biol 22(7):2047-56
2)	Kassir Y, et al. (2003) Transcriptional regulation of meiosis in budding yeast. Int Rev Cytol 224():111-71
3)	Kassir Y, et al. (1988) IME1, a positive regulator gene of meiosis in S. cerevisiae. Cell 52(6):853-62

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