IMD3/YLR432W Summary

IMD3 BASIC INFORMATION

Standard Name	IMD3 1
Systematic Name	YLR432W
Feature Type	ORF, Verified
Description	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed (2)
Name Description	IMP Dehydrogenase 1

GO Annotations	All IMD3 GO evidence and references
	View Computational GO annotations for IMD3
Molecular Function
Manually curated	IMP dehydrogenase activity (TAS)
Biological Process
Manually curated	GTP biosynthetic process (TAS)
Cellular Component
High-throughput	cytoplasm (IDA) plasma membrane enriched fraction (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All IMD3 Phenotype details and references
Classical genetics
null	resistance to mycophenolic acid: normal viable
overexpression	resistance to 6-azauracil: increased
Large-scale survey
null	viable

Interactions	IMD3 All interactions details and references
	109 total interaction(s) for 87 unique genes/features.
Physical Interactions	Affinity Capture-MS: 93 Affinity Capture-RNA: 1 Co-purification: 1 PCA: 3 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 2 Synthetic Growth Defect: 2

Sequence Information

ChrXII:1002554 to 1004125 | |

Last Update

Coordinates: 2006-01-09 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1572	1002554..1004125	2006-01-09	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004424

IMD3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for IMD3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IMD3]

1)	Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30
2)	Hyle JW, et al. (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J Biol Chem 278(31):28470-8

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