IMD3/YLR432W Summary Help

Standard Name IMD3 1
Systematic Name YLR432W
Feature Type ORF, Verified
Description Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD3 has a paralog, IMD4, that arose from the whole genome duplication (2, 3)
Name Description IMP Dehydrogenase 1
Chromosomal Location
ChrXII:1002557 to 1004128 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All IMD3 GO evidence and references
  View Computational GO annotations for IMD3
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 8 genes
Resources
Pathways
Classical genetics
null
overexpression
Large-scale survey
null
Resources
165 total interaction(s) for 127 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 104
  • Affinity Capture-RNA: 3
  • Co-purification: 2
  • PCA: 4
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 40
  • Positive Genetic: 2
  • Synthetic Growth Defect: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 523
Molecular Weight (Da) 56,584
Isoelectric Point (pI) 7.38
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:1002557 to 1004128 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1572 1002557..1004128 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004424
References cited on this page View Complete Literature Guide for IMD3
1) Escobar-Henriques M and Daignan-Fornier B  (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30
2) Hyle JW, et al.  (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J Biol Chem 278(31):28470-8
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61