IMD1/YAR073W Summary

IMD1/YAR073W Summary

Standard Name	IMD1 1
Systematic Name	YAR073W
Feature Type	ORF, Dubious
Description	Nonfunctional protein with homology to IMP dehydrogenase; blocked reading frame, located close to the telomere; not expressed at detectable levels; YAR073W and YAR075W comprise a continuous reading frame in most strains of S. cerevisiae; YAR073W/YAR075W together have a paralog, IMD2, that arose from a segmental duplication (2, 3)
Name Description	IMP Dehydrogenase 1

Chromosomal Location	ChrI:227742 to 228953 \| ORF Map \| GBrowse

Gene Ontology Annotations All IMD1 GO evidence and references

	View Computational GO annotations for IMD1
Molecular Function
Manually curated	NOT IMP dehydrogenase activity (IMP) molecular_function unknown (ND)
Biological Process
Manually curated	biological_process unknown (ND)
Cellular Component
Manually curated	cellular_component unknown (ND)

Mutant phenotypes All IMD1 Phenotype evidence and references

Classical genetics
null	resistance to mycophenolic acid: normal viable
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All IMD1 Protein evidence and references

Localization	YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| Fungal Orthogroups Repository \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrI:227742 to 228953 | |

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1212	227742..228953	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| E.C. \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000000095

References cited on this page View Complete Literature Guide for IMD1

1)	Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30
2)	Hyle JW, et al. (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J Biol Chem 278(31):28470-8
3)	Katju V, et al. (2009) Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Genome Biol 10(7):R75